This research study will evaluate the safety and efficacy of a study drug called TGR-1202 in combination with another study drug called ublituximab compared to TGR-1202 alone as a possible treatment for Diffuse Large B-cell Lymphoma (DLBCL) that has come
Ages Eligible for Study: 18 Years and older (Adult, Senior)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Histologically confirmed diagnosis of: B-cell NHL with histological subtype limited to the following:
a. Follicular Lymphoma (FL) of Grade 1, 2, or 3a;
b. Marginal Zone Lymphoma (MZL) (splenic, nodal, or extranodal); or
c. Mantle Cell Lymphoma (MCL) – with documentation of either overexpression of cyclin D1 or t(11;14).
> Any major surgery, chemotherapy or immunotherapy within the last 21 days
> Evidence of hepatitis B virus, hepatitis C virus or known HIV infection
> Autologous hematologic stem cell transplant within 3 months of study entry.
> Prior Allogeneic hematologic stem cell transplant is excluded
> Prior therapy with a PI3K delta inhibitor